The new study, from Germany, has added to the scientific evidence linking deficiency of testosterone with increased death from all-cause mortality.
The results should serve as a warning for men with low testosterone to have a healthier lifestyle, including weight control, regular exercise and a healthy diet.
In the study, Haring and co-workers from Ernst-Moritz-Arndt University of Greifswald, looked at death from any cause in nearly 2,000 men aged 20 to 79 years who were living in northeast Germany and who participated in the Study of Health in Pomerania ( SHIP ).
Follow-up averaged 7 years.
At the beginning of the study, 5% of these men had low blood testosterone levels, defined as the lower end of the normal range for young adult men.
The men with low testosterone were older, more obese, and had a greater prevalence of diabetes and high blood pressure, compared with men who had higher testosterone levels.
Men with low testosterone levels had more than 2.5 times greater risk of dying during the next 10 years compared to men with higher testosterone. This difference was not explained by age, smoking, alcohol intake, level of physical activity, or increased waist circumference.
In cause-specific death analyses, low testosterone predicted increased risk of death due to cardiovascular disease and cancer but not death of any other single cause. ( Xagena )
Source: 90th Annual Meeting - The Endocrine Society, 2008